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Actinic keratosis (AK), sometimes called solar keratosis or senile keratosis,2 is a pre-cancerous area of thick, scaly, or crusty skin.3 They are believed to form when skin gets damaged by UV radiation from the sun. Actinic keratoses often feels as dry or rough skin and commonly ranges between 2 and 6 millimeters, but can grow to be several centimeters in diameter.4


Your Doctor has discussed the best option to treat you and has prescribed GLENTRIZTM cream to treat your Actinic Keratosis.1

GLENTRIZTM cream is simple to use.


Condition Information
Actinic Keratosis lesions (plural: Actinic Keratoses) are skin lesions that occur as a result of long-term exposure to Ultra Violet (UV) radiation from sun. Actinic Keratosis may appear as dry scaly patches or pink brown spots on sun-exposed skin.

They indicate that some sun damage has occured and are important to treat because, in a small number of cases they can lead to a some types of skin cancer.

Actinic Keratosis are very common in fair-skinned people and occur partly because of local effects that UV radiation can have on the imune system. GlentrizTM cream works with your body’s immune response to help clear these lesions.



  1. GLENTRIZTM should be applied prior to your normal bedtime.
  2. GLENTRIZTM cream needs to remain on your skin for 8 (6 – 10) hours
  3. During the 6 – 10 hours treatment period, showering or bathing should
    be avoided.
  4. Before applying GLENTRIZTM cream you should wash the treatment area
    with mild soap and water.
  5. Allow the area to dry thoroughly.
  6. Open the sachet and apply the cream as a thin layer and rub it onto the
    affected area until the cream is absorbed.
  7. Do not cover the affected area with a dressing
  8. After the 6 – 10 hours treatment period, GLENTRIZTM cream can be
    washed off with mild soap and water.



GLENTRIZTM is a cream that you apply to your superficial BCC. GLENTRIZTM works by stimulating your own immune system to recognise and destroy the skin cancer.
During treatment, your treated area of skin is likely to appear noticeably different from normal skin. This is a sign that GLENTRIZTM treatment is working.

Actinic Keratosis Before and After Pictures in Charlotte, NC*



You may experience local skin reactions at the site of treatment.

Your skin may

  • Feel itchy
  • Look flaky or scaly
  • Feel crusty
  • Develop scabs
  • Look and feel slightly swollen, or even hard

If you are feeling any discomfort from the treatment, you can take a break from treatment for a few days until the reactions subside, then resume the application of GLENTRIZTM cream as prescribed by your doctor. The rest periods will not interfere with your treatment plan.


Contact your Doctor if you experience any sign or symptom at the application site that restricts or prohibits your daily activity, or makes application of the cream difficult.


Please Note:
You need to minimise or avoid exposure to natural or artificial sunlight.



Your Doctor will explain how often to use GLENTRIZTM cream.

  • You will need to apply GLENTRIZTM 3 times per week (example: Monday, Wednesday and Friday) prior to normal sleeping hours, and leave on the skin for approximately 8 hours.
  • Continue GLENTRIZTM treatment for 4 weeks.
  • After a 4-week treatment-free period your Doctor will assess the treated area to determine clearance of your Actinic Keratosis.
  • If any Actinic Keratosis persists in the treatment area your Doctor will recommend that you apply GLENTRIZTM 3 times per week for an additional 4 weeks (for a maximum total treatment duration of 8 weeks).
  • Your Doctor may want to see you about 8 weeks after starting treatment.


Think about your lifestyle then mark on this chart which days will suit you best to apply your GLENTRIZTM cream.

You can use this table to record each time you apply the treatment – this will help you keep to the treatment plan prescribed by your Doctor.



  1. GLENTRIZTM Professional Information. January 2021.
  2. Rapini RP, Bolognia J, Jorizzo JL (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. pp. Chapter 108. ISBN 978-1-4160-2999-1.
  3. Prajapati V, Barankin B (May 2008). “Dermacase. Actinic keratosis”.
    Canadian Family Physician. 54 (5): 691, 699. PMC 2377206. PMID 18474700
  4. Moy RL (January 2000). “Clinical presentation of actinic keratoses and squamous cell carcinoma”. Journal of the American Academy of Dermatology. 42 (1 Pt 2): 8–10. doi:10.1067/mjd.2000.103343. PMID 10607350.

S4 GLENTRIZTM Cream 5 % w/w (Cream): Registration Number: 49/34/0556.
Each 250 mg sachet contains 12,5 mg of imiquimod.

For full prescribing information refer to the professional information approved by
the South African Health Products Regulatory Authority. January 2021.
Glenmark Pharmaceuticals South Africa (Pty) Ltd, 2nd Floor, Building D, Stoneridge
Office Park, 8 Greenstone Place, Greenstone, Edenvale, Gauteng, 1609, Tel: +27
(0)11 564 3900 GLET22/06/2021

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