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Your Insulin User Guide

Understanding Normal Insulin Secretion

In a person without diabetes, the pancreas releases insulin throughout the day (the
purple line) to keep the blood glucose values within a certain range. When meals are
eaten, more insulin is secreted by the pancreas to deal with the glucose load of the meal
(see the green peaks). So the pattern looks like this:1


As a patient with type 2 diabetes, you may require insulin to achieve glycaemic control and remain controlled. The insulin preparations currently available in South Africa are summarised in the table on page 2.2 They differ in the times that they take to start working after injection (onset of action), the time to maximum peak effect, that they continue to have an effect (duration of action) and whether they are human insulins or analogue insulins.2 Human insulins are laboratory-made insulins (you would think they come from humans, but they don’t).3 Analogue insulins are also made in a laboratory –
but are modified to affect how quickly or slowly they act.2



You may have either been prescribed a disposable device (SoloStar®) OR a reusable device (ALLSTAR®)5,6

For Lantus® SoloStar® use click here
For Lantus® ALLSTAR® use click here

1. Polonsky KS, et al. Twenty-Four-Hour Profiles and Pulsatile Patterns of Insulin Secretion in Normal and Obese Subjects. Journal of Clinical
Investigation. Volume 81, February 1988. Pg 442-443. 2. The 2017 SEMSDA Guideline for the Management of Type 2 Diabetes. JEMDSA 2017,
Volume 21, Number 1 (Supplement 1). Pg. S1-S196. 3. Insulin Types and Information. [updated 15 Jan 2019; accessed 18 March
2020]. Available from: 4. Package Insert. Lantus® solution for injection. 26 April 2018. 5.
Lantus® Solostar -Instructions for use. 6. Lantus® ALLSTAR® – Instructions for use. 7. Inzucchi S, Bergenstal R, Buse J, et al. Management of
Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach. Update to a Position Statement of the American Diabetes Association and
the European Association for the Study of Diabetes. Diabetes Care 2015;38:46. Available from:
8. Gerstein HC, Yale JF, Harris SB, Issa M, Stewart JA, Dempsey E. A randomized trial of adding insulin glargine vs. avoidance of insulin in people
with type 2 diabetes on either no oral glucose lowering agents or submaximal doses of metformin and/or sulphonylureas. The Canadian INSIGHT
(Implementing New Strategies with Insulin Glargine for Hyperglycaemia Treatment) Study. Diabetic Medicine. 2006 Jul;23(7):736-42. 9. Becton,
Dickinson and Company. Injection Site Selection. [accessed 4/8/2019; cited 18/3/2020]. Available from:
diabetes-care/diabetes-learning-center/managing-diabetes-with-insulin/how-to-inject-insulin/injection-sites. 10. Becton, Dickinson and Company.
Rotating Injection Sites. [accessed 4/8/2019; cited 18/3/2020]. Available from: https://www.

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