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Trifluridine and tipiracil is a combination medication used to treat metastatic gastric, gastroesophageal, and colorectal cancer. It may also be prescribed for other conditions.
It is essential to take Lonsurf as instructed to ensure your treatment is as effective as possible. Below are key points to remember:
Below are common side effects that may affect more than one-third of patients taking Lonsurf. Please note, you may not experience these side effects.
| Decreased white blood cells (WBCs) and increased risk of infection | A blood test will be done two weeks after starting Lonsurf and before starting a new cycle to monitor your white blood cells, haemoglobin, platelet count, and kidney function. Take the following precautions to protect yourself from infection: |
| – Wash your hands often, especially before eating and after using the bathroom. | |
| – Avoid crowds and individuals with fevers, flu, or other infections. | |
| – Maintain good personal hygiene. | |
| Signs of infection: | – Fever (temperature over 38°C) |
| – Chills | |
| – Sore throat | |
| – Burning sensation while urinating | |
| Decreased haemoglobin (part of the red blood cells that carry iron and oxygen) | Low haemoglobin may make you feel more tired or fatigued. |
| – Aim for 7–8 hours of sleep per night. | |
| – Balance work and rest. | |
| – Stay as active as possible, but rest when needed. | |
| – You might notice you are paler than usual. | |
| Low platelet count and increased risk of bleeding | When your platelet count is low, you may bruise or bleed more easily. |
| – Be cautious to avoid bruises, cuts, or burns. | |
| – Blow your nose gently, and avoid picking your nose. | |
| – Brush your teeth gently with a soft toothbrush and maintain good oral hygiene. | |
| – When shaving, use an electric razor instead of a blade. | |
| – Use a nail file instead of nail clippers. | |
| Contact us if you experience any of the following bleeding symptoms: | |
| – A bloody nose lasting more than 5 minutes despite pressure | |
| – A cut that continues to bleed despite pressure | |
| – Gums that bleed excessively when brushing or flossing | |
| If you experience any severe headaches, blood in your urine or stool, or cough up blood, visit the emergency room immediately. | |
| Nausea or vomiting | – Eat and drink slowly. |
| – Drink 8–10 glasses of water or fluids daily unless your doctor advises otherwise. | |
| – Eat smaller, more frequent meals instead of large ones. | |
| – Avoid spicy, fried, and greasy foods. | |
| – Rest after meals and avoid vigorous exercise immediately after eating. | |
| Fatigue | – You may feel more tired than usual. |
| – Stay active, but take rest when needed. | |
| – Try to do activities when you feel most energetic. | |
| Diarrhoea (loose and/or urgent bowel movements) | – Drink 8–10 glasses of water or fluids daily unless your doctor advises otherwise. |
| – Eat smaller, more frequent meals. | |
| – Eat bland, low-fibre foods (e.g., bananas, rice, chicken, potatoes). | |
| – Avoid high-fibre foods (e.g., raw vegetables, fruits, whole grains). | |
| – Avoid gas-causing foods (e.g., beans, broccoli, onions). | |
| – Avoid lactose-containing foods (e.g., milk, yogurt). | |
| – Try grated apple that has stood until brown, or porridge made with Maizena. | |
| Decreased appetite or weight loss | Talk to your doctor if you notice any sudden weight loss while taking Lonsurf. |
| When you feel like eating: | |
| – Eat smaller, frequent meals. | |
| – Keep snacks nearby for easy access. | |
| – Consider liquid nutritional supplements. |
Because Lonsurf remains in your body for several days after administration, the drug may be present in your urine, stool, sweat, or vomit. Follow these instructions every day while taking Lonsurf to keep yourself, loved ones, and the environment safe:
