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Doctors were first alerted to the existence of AIDS when patients clinically presented with opportunistic infections.1a

What is an opportunistic infection?

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An opportunistic infection is an infection that is more frequent or more severe because of a weakened immune system, called HIV immunosuppression.2a
When a person with HIV gets an opportunistic infection, they will get diagnosed with AIDS (also known as HIV stage 3), the most serious stage of HIV infection.2b
HIV treatments have become better at keeping the immune system strong and the level of HIV low. As a result, opportunistic infections have become less common, compared with when HIV first become a public health issue, where the rate of opportunistic infections were high.1b,2a
It wasn’t until the mid-1990s with the introduction of highly effective combination antiretrovirals that opportunistic infection-related illness and death in persons with HIV was reduced. To this day, if a person infected with HIV is not virally suppressed, then opportunistic infections will continue to cause preventable illness and death.1b
Learn here more about opportunistic infections and preventative measures to keep them under control.

Why would a person get an opportunistic infection?

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If a patient takes their HIV treatment properly, the levels of HIV virus in their body are kept low. This allows their immune fighting cells to recover and fight off these opportunistic infections.2a,q
It is important to know about the most common infections that occur in people living with HIV so that they can be detected early and treated.2c

Types of opportunistic infections

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Medical name of infectionType of infectionHow it presents 
Oropharyngeal and oesophageal candidiasis Fungal infectionThis illness is caused by an infection with a common type of fungus called Candida.2d Candidiasis is most often observed in patients with a CD4 cell count of less than 200 cells/mm3.1c However, candidiasis is only considered an opportunistic infection when it infects the oesophagus (swallowing tube) or lower parts of the lung.2d Signs include painless, creamy white, plague-like lesions that occur on or in the mouth area.1d
Cryptococcosis (also called cryptococcal disease/ meningitis)Fungal infection2xCryptococcal meningitis is a common opportunistic infection, and a leading cause of death in people living with HIV.3a
Most cases are observed in patients who have CD4 cell counts < 100 cells/μL.1u In HIV-infected patients, cryptococcosis commonly presents as a type of meningitis with fever, malaise, and headache,1u though it can also infect any part of the body, for example the lungs, and cause pneumonia.2x
Cytomegalovirus (CMV)Viral infection2gCan infect multiple parts of the body  and cause pneumonia, gastroenteritis, infection of the brain, and sight-threatening retinitis (infection of the back of the eye).2g Retinitis may present with floaters or vision deficits. If CMV infects the colon or oesophagus it can cause symptoms of weight loss, loss of appetite, stomach pain, nausea and fever.1v
Diarrhoeal diseaseBacteria/ParasiteDifferent types of organisms can cause diarrhoea.2f,h,i Usually picked up from contaminated food or water.2i People with HIV and low CD4 cell counts have more severe diarrhoea and associated illness as they have little immunity to fight off the germs.1e
Herpes simplex virus (HSV)Viral infectionA common virus, that for most people, does not cause major problems but in HIV-infected patients, can cause more serious infections. HSV can cause painful cold sores (fever blisters) in and around the mouth or painful ulcers in the genital area.2j
Human papillomavirus (HPV)Viral infectionCertain types of HPV can increase the risk of cervical cancer (cancer of the lower part of the uterus in a woman).1f,w,2e HIV infection and low CD4 cell count are strongly associated
with HPV infection and with the development of cancerous cervical cells.1g
Kaposi’s sarcomaViral infectionThis cancer, also known as KS, is caused by a virus that causes the small blood vessels (capillaries) to grow abnormally. Because capillaries are located throughout the body, KS can occur anywhere, seen as pink or purple spots on the skin that can be raised or flat. KS can become life-threatening when it affects organs inside the body, such as the lung, lymph nodes, or intestines.1y,2k
Tuberculosis (TB)Bacterial infectionThis infection is caused by the bacteria Mycobacterium tuberculosis. Inhaling the bacteria can lead to an infection in the lungs.2l Classis symptoms include cough, fever, night sweats and weight loss.1z,2l Although the disease usually occurs in the lungs, it may also affect and present in other parts of the body, especially if left untreated.2l,3e
Mycobacterial diseases or infectionsMycobacteriaMycobacteria live in our environment, including in the soil and dust particles. In people with severely damaged immune systems, infections with these bacteria spread throughout the body and can be life-threatening.2m
PneumoniaBacteria, virus or fungus2nPneumonia is a severe infection of one or both of the lungs. Symptoms include a cough (with mucus), fever, chills and trouble breathing. Pneumonia occurs in people with weakened immune systems and can be life-threatening. Vaccines are effective against some types of pneumonia.2n
ToxoplasmosisParasiteCarried by animals, this parasite is spread through inhaling dust or eating food contaminated with animal excretions. Cats are often the cause.2o
Varicella zoster and herpes zosterViral infectionVaricella zoster is commonly known as chickenpox and Herpes zoster is commonly known as shingles. Shingles is more common in the elderly or immunocompromised such as in HIV. Severe complications of shingles can include blindness and other nerve-related damage.1h,i

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